Patients who suffer from pain and discomfort due to acute or chronic musculoskeletal conditions can consider using supplements containing PEA. The pain-relieving benefits of PEA could be enhanced further by combining it with other safe and natural compounds given below:
Research studies have revealed that magnesium could play a key role in preventing the sensitization of the nervous system and attenuating pain hypersensitivity. Regular use of supplements containing this mineral is linked to a reduced risk of diseases characterized by inflammation in the joints and muscles such as osteoarthritis, spondylitis, and low back pain. 
White willow bark
White willow bark contains a compound called salicin that is found to produce an action similar to that of aspirin. Research studies have revealed that this herb may be used to relieve pain and fever linked to conditions such as back pain, rheumatoid arthritis, fever, flu, muscle pain, and osteoarthritis.  
Luteolin is revered for its natural anti-inflammatory and analgesic properties. It would provide long-term relief from the symptoms of musculoskeletal symptoms without causing any serious side effects. It may also regulate the response of the immune cells thereby preventing inflammation and damage to the tissues of the joints and muscles. 
Natural vs. modern drugs
Unlike modern drugs that are known to cause serious side effects, especially when used over a longer duration, the supplements containing PEA are safe and cause no adverse effects.
PEA possesses a natural ability to reduce pain and discomfort by regulating the body’s own immunological and physiological mechanisms involved in controlling inflammation. These compounds work by supporting the body’s natural ability to reduce inflammation and help to restore healthy immunological functions.
Modern treatments, on the other hand, reduce pain only temporarily. Hence, it is advisable to choose natural supplements containing PEA to relieve pain and discomfort in a safe and effective way.
Modern scientific research has suggested that PEA could be a promising therapeutic agent that can be used in the management of musculoskeletal conditions characterized by pain and discomfort in the muscles, bones, joints, tendons, and ligaments.
The natural therapeutic potential of PEA would regulate the functions of your immune system, control inflammation, and provide relief from pain.
Regular use of PEA in the form of diet or supplements needs to be encouraged to ease pain and improve the quality of life, while avoiding the side effects associated with the long-term use of pain killers.
 Xiaoying Fan, Kexin Du, Na Li, Zhonglei Zheng, Yan Qin, Jing Liu, Rong Sun, Yuqiang Su, Evaluation of Anti-Nociceptive and Anti-Inflammatory Effect of Luteolin in Mice, 2018, 018;37(4):351-364, doi: 10.1615, PMID: 30806241