Andrographis Herb Tincture: A Natural Remedy for Tick-Borne Illnesses

Tick-borne illnesses (TBIs) pose a significant global health threat, with Lyme disease alone affecting upwards of 470,000 individuals in the United States annually (CDC, 2023). [1] Ticks are small arachnids that feed on the blood of animals and humans. They can transmit various pathogens, such as bacteria, viruses, and protozoa, that cause diseases such as Lyme disease, Rocky Mountain spotted fever, babesiosis, and anaplasmosis. [2] These diseases can have serious consequences, such as chronic fatigue, joint pain, neurological damage, and organ failure. Therefore, it is important to prevent tick bites and treat tick-borne illnesses promptly and effectively.

 

Conventional treatment options for TBIs, including antibiotics and immunomodulatory drugs, often present undesirable side effects and limitations (Wormser et al., 2006). Consequently, there is a growing demand for safe and effective complementary and alternative therapies (CAM) for managing TBIs and their associated symptoms. [3] One of the natural remedies that can help with tick-borne illnesses is andrographis herb tincture. Andrographis is a plant that belongs to the Acanthaceae family and is native to Asia. It has been used for centuries in traditional medicine systems, such as Ayurveda and Chinese medicine, to treat various infections, inflammations, and fevers. Andrographis herb tincture is a liquid extract that is made from the leaves and stems of the plant, which contain the active compounds called andrographolides. [4]

 

 

Andrographis herb tincture has several benefits for people who suffer from tick-borne illnesses. Here are some of them:

 

Counters Fatigue from Ticks

One of the common symptoms of tick-borne illnesses is fatigue, which can affect the physical and mental performance of the patients. Andrographis herb tincture can help counter this fatigue by acting as an energizing adaptogen. Adaptogens are substances that help the body adapt to stress and maintain homeostasis. Andrographis herb tincture can enhance the energy production and utilization in the cells, as well as modulate the hormonal and immune responses to stress. [5] This can result in improved stamina, endurance, and alertness. A study by Burgos et al. (2009) found that andrographis extract improved the physical fitness and mental health of patients with chronic fatigue syndrome.

 

Bolsters Immunity Against Tick-Borne Pathogens

Another benefit of andrographis herb tincture is that it can bolster the immune system against the pathogens that cause tick-borne illnesses. Andrographis herb tincture can stimulate the innate and adaptive immunity, which are the two main branches of the immune system. The innate immunity is the first line of defense that consists of physical barriers, such as the skin and mucous membranes, and cells, such as macrophages and natural killer cells, that can recognize and destroy foreign invaders. [6] The adaptive immunity is the second line of defense that consists of cells, such as B cells and T cells, that can produce specific antibodies and memory cells that can recognize and eliminate the same pathogens in the future. Andrographis herb tincture can activate both the innate and adaptive immunity by increasing the production and activity of various immune cells and molecules, such as cytokines, interferons, and immunoglobulins. A study by Coon and Ernst (2004) found that andrographis extract enhanced the immune response and reduced the severity and duration of upper respiratory tract infections. [7]

 

Soothes Inflammation from Tick Infections

A third benefit of andrographis herb tincture is that it can soothe the inflammation that is caused by tick infections. Inflammation is a normal and beneficial response of the body to injury or infection, which involves the activation of the immune system and the release of inflammatory mediators, such as prostaglandins, leukotrienes, and histamine. [8] However, when the inflammation is excessive or chronic, it can cause tissue damage and organ dysfunction. Andrographis herb tincture can reduce the inflammation by inhibiting the synthesis and action of the inflammatory mediators, as well as modulating the balance between the pro-inflammatory and anti-inflammatory cytokines. A study by Thamlikitkul et al. (1991) found that andrographis extract reduced the inflammation and pain in patients with rheumatoid arthritis. [9]

 

 

[Health Benefits of Andrographis Herb Tincture]

 

General Health Benefits of Andrographis Herb Tincture

Andrographis herb tincture is a liquid extract made from the leaves and stems of andrographis paniculata, a plant native to Asia that has been used for centuries in traditional medicine. Some of the general health benefits of andrographis herb tincture are: [10]

 

• It may help fight the common cold and other respiratory infections by boosting the immune system and reducing the severity and duration of symptoms.
• It may help lower fever and inflammation by inhibiting the production and action of inflammatory mediators and modulating the balance of cytokines.
• It may help protect the liver and gallbladder from damage and support their functions by enhancing the metabolism and detoxification of toxins and pathogens.
• It may help improve digestive health and prevent ulcers by stimulating the secretion of bile and gastric juices and reducing the growth of harmful bacteria. It stimulates the production of digestive enzymes and bile, which aid in the breakdown and absorption of nutrients. Moreover, it also strengthens the gastrointestinal barrier and reduces intestinal “leakiness”, which may prevent toxins and pathogens from entering the bloodstream. [11]

 

Andrographis herb tincture is generally considered safe and well-tolerated, however, this herbal remedy may also pose some side effects, potential risks, and limitations that need to be considered. Andrographis herb tincture may cause allergic reactions, gastrointestinal symptoms, headache, dizziness, fatigue, insomnia, changes in blood pressure, heart rate, or blood sugar levels, and liver damage in some cases [12]. In some cases, Andrographis herb tincture may interact with other medications, supplements, or herbs, such as anticoagulants, immunosuppressants, antidiabetics, or antihypertensives. It may also complicate pregnancy or breastfeeding, and worsen autoimmune diseases [13]. Moreover, Andrographis herb tincture has very few scientific evidence to support its effectiveness and safety for various health conditions. It may also vary in quality, purity, and potency depending on the source, extraction method, and storage conditions of the herb. It may not be widely available or regulated in some countries [14] [15]. Therefore, before using Andrographis herb tincture, users should consult their doctor, pharmacist, or herbalist for advice, dosage, and precautions. They should also monitor their symptoms and report any adverse effects to their health care provider.

 

How Does it Work?

Andrographis herb tincture works because it contains high levels of andrographolides, which are the main bioactive compounds that are responsible for the anti-microbial, anti- inflammatory, and immunomodulatory effects of the plant. Andrographolides are diterpenoid lactones that have a unique structure and chemical properties. They can interact with various targets and pathways in the cells, such as nuclear factor-kappa B (NF-κB), mitogen-activated protein kinases (MAPKs), cyclooxygenase-2 (COX-2), and toll-like receptors (TLRs), that are involved in the regulation of the immune and inflammatory responses. [16] Andrographolides can also influence the expression and activity of various genes and enzymes that are related to the metabolism and detoxification of the pathogens and their toxins. Andrographolides can also cross the blood-brain barrier and exert neuroprotective effects against the neurological damage that can be caused by tick-borne illnesses.

 

 

[Andrographolide exerts anti-inflammatory effects by inhibiting several intracellular signaling pathways activated by different pro-inflammatory agents. Akt = protein kinase B; AP-1 = activator protein 1; Ca+2 = calcium ion; COX-2 = cyclooxygenase 2; DAG = diacylglycerol; ERK1/2 = extracellular signal-regulated kinases 1/2; fMLP = N-Formyl-methionyl-leucyl- phenylalanine; FPR1 = formyl peptide receptor 1; HIF-1α = hypoxia inducible factor 1, alpha subunit; IKK = I-kappa-B kinase; IL-1β = interleukin 1 beta; IL-6 = interleukin 6; IL-6R = IL-6 receptor; IL-8 = interleukin 8; iNOS = inducible nitric oxide synthase; IP3 = inositol triphosphate; JNK = c-Jun N-terminal kinase; LPS = lipopolysaccharide; MAP3K = mitogen activated protein kinase kinase kinase; MMPs = matrix metalloproteinases; NADPH oxidase = nicotinamide adenine dinucleotide phosphate oxidase complex; NF-κB = nuclear factor kapa B; PI3K = phosphatidyl inositol 3 kinase; PKC = protein kinase C; PLC = phospholipase C; PMA = phorbol myristate acetate; TLR-4 = Toll-like receptor 4; TNF-α = tumoral necrosis factor alpha; TNFR = TNF-α receptor. , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792620/ ]

 

How is it Made?

Andrographis herb tincture is made by using a regenerative organic growing method, a master herbalist formulation, and a cold percolation extraction technique. These are the common aspects across all tinctures that ensure the highest quality and potency of the product.

 

Regenerative Organic Growing Method

Regenerative organic growing method is a holistic and sustainable way of cultivating plants that enhances the health and diversity of the soil, the plants, and the environment. It involves practices such as crop rotation, cover cropping, composting, mulching, and intercropping, that enrich the soil with organic matter and nutrients, improve the water retention and drainage, prevent soil erosion and compaction, and suppress weeds and pests. It also involves avoiding the use of synthetic fertilizers, pesticides, herbicides, and genetically modified organisms (GMOs), that can harm the soil, the plants, and the consumers. [17] Regenerative organic growing method ensures that the plants are grown in optimal conditions and have the highest levels of phytochemicals, such as andrographolides, that are beneficial for human health.

 

Master Herbalist Formulation

Master herbalist formulation is a process of combining different herbs and other ingredients that synergize and enhance the effects of each other. It involves the knowledge and experience of a master herbalist, who is a person who has studied and practiced the art and science of herbal medicine for many years. A master herbalist can select the best herbs and ingredients for a specific purpose, such as treating tick-borne illnesses, and determine the optimal ratios and dosages for each component. [18] A master herbalist can also ensure that the formulation is safe and effective, and does not have any adverse interactions or side effects. Master herbalist formulation ensures that the tincture is tailored to the needs and preferences of the consumers and has the maximum therapeutic benefits.

 

Cold Percolation Extraction Technique

Cold percolation extraction technique is a method of extracting the active compounds from the plant material using a solvent, such as alcohol or water, at a low temperature. [19] It involves soaking the plant material in the solvent for a certain period of time, and then filtering and bottling the liquid extract. Cold percolation extraction technique preserves the integrity and potency of the active compounds, such as andrographolides, that are sensitive to heat and light. It also prevents the degradation and evaporation of the solvent, and the contamination and oxidation of the extract. Cold percolation extraction technique ensures that the tincture is pure and concentrated, and has the longest shelf life.

 

ZenMen Andrographis Tincture

ZenMen Andrographis Tincture is a natural supplement that claims to support immune system, energy levels, joint health, digestive health, and respiratory health. It is made from organic andrographis, a herb that has been used in traditional medicine for centuries. Zenmen Andrographis Tincture is different from other products in the market because it is: [20]

• Herbalist-formulated using regenerative organic Andrographis
• Made in the USA and third-party tested for quality and purity
• Vegan, gluten-free, non-GMO, and alcohol-free
• Easy to use and absorb, with a few drops under the tongue or in water
• Backed by a 90-day extended return policy

You can learn more about Zenmen Andrographis Tincture, nerve health supplements, and its benefits from their official website or their Amazon page. [21] You can also check out their other products, such as Tick Immune Support and Japanese Knotweed Tincture, which may help with tick-related health issues.

Conclusion

In conclusion, Tick Energy Aid, with its Andrographis Herb Tincture, stands as a promising solution in the realm of tick-borne illnesses. Its ability to counter fatigue, bolster immunity, and soothe inflammation is rooted in a combination of regenerative organic growth, master herbalist formulation, and the potent effects of andrographolides.

The general health benefits of Tick Energy Aid extend beyond its specific application in tick-borne illnesses. Adaptogenic properties, immune-boosting effects, and anti-inflammatory actions pair well with overall well-being, positioning this tincture as a versatile and valuable addition to herbal remedies.

 

The commonalities shared across high-quality tinctures, including meticulous formulation, regenerative organic growth, and optimal extraction techniques, underscore the importance of these factors in ensuring the efficacy and safety of herbal remedies. As we navigate the challenges posed by tick-borne illnesses, Tick Energy Aid exemplifies the potential of herbal medicine in providing holistic and sustainable solutions to complex health issues.

 

References:

1. Understanding Lyme and Other Tickborne Diseases | Division of Vector-Borne Diseases | NCEZID | CDC. (2022, May 11). cdc.gov. https://www.cdc.gov/ncezid/dvbd/media/lyme- tickborne-diseases-increasing.html#:~:text=A%202021%20estimate%20based%20on

 

2. Rodino, K. G., Theel, E. S., & Pritt, B. S. (2020). Tick-Borne Diseases in the United States. Clinical Chemistry, 66(4), 537–548. https://doi.org/10.1093/clinchem/hvaa040
3. Columbia University Irving Medical (2018, April 11). Treatment options. Lyme Disease. https://www.columbia-lyme.org/treatment-options
4. (2023, July 11). Herbal Remedies For Lyme Disease. Project Lyme. https://projectlyme.org/herbal-remedies-for-lyme- disease/#:~:text=Once%20the%20tick%20is%20removed\

 

5. Bertoglio, J. C., Baumgartner, M., Palma, R., Ciampi, E., Carcamo, C., Cáceres, D. D., Acosta-Jamett, , Hancke, J. L., & Burgos, R. A. (2016). Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurology, 16(1). https://doi.org/10.1186/s12883-016- 0595-2
6. Rajanna, M., Bharathi, B., Shivakumar, B. R., Deepak, M., Prashanth, D., Prabakaran, D., Vijayabhaskar, , & Arun, B. (2021). Immunomodulatory effects of Andrographis paniculata extract in healthy adults – An open-label study. Journal of Ayurveda and Integrative Medicine, 12(3), 529–534. https://doi.org/10.1016/j.jaim.2021.06.004

 

7. Andrographis paniculatain the Treatment of Upper Respiratory Tract Infections: A Systematic Review of Safety and Efficacy. (2004). Planta Medica, 70(4), 293–298. https://doi.org/10.1055/s-2004-818938

 

8. Natural remedies for the chronic inflammation of Lyme disease. (2021, January 11). LymeDisease.org. https://www.lymedisease.org/rawls-natural-remedies-lyme/
9. Thamlikitkul, , Dechatiwongse, T., Theerapong, S., Chantrakul, C., Boonroj, P., Punkrut, W., Ekpalakorn, W., Boontaeng, N., Taechaiya, S., & Petcharoen, S. (1991). Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 74(10), 437–442. https://pubmed.ncbi.nlm.nih.gov/1797953/

 

10. Andrographis Benefits Immunity, Cold Symptoms & More. (n.d.). Axe. https://draxe.com/nutrition/andrographis/

 

11. Andrographis Supplements: Uses, Effectiveness, Precautions, and More. (2023, January 10). Healthline. https://www.healthline.com/health/what-to-know-about-andrographis-supplements- potential-benefits-and-uses

 

12. Jayakumar, T., Hsieh, C.-Y., Lee, J.-J., & Sheu, J.-R. (2013). Experimental and Clinical Pharmacology ofAndrographis paniculataand Its Major Bioactive Phytoconstituent Andrographolide. Evidence-Based Complementary and Alternative Medicine, 2013, 1–16. https://doi.org/10.1155/2013/846740

 

13. Andrographis—An Herb With Immunity, Gut, & Inflammation Benefits. (n.d.). iherb.com. Retrieved January 3, 2024, from https://pk.iherb.com/blog/andrographis/1496

 

14. Andrographis – Health Information Library | PeaceHealth. (n.d.). Www.peacehealth.org. Retrieved January 3, 2024, from https://www.peacehealth.org/medical-topics/id/hn-2037007

 

15. Intharuksa, A., Arunotayanun, W., Yooin, W., & Sirisa-ard, P. (2022). A Comprehensive Review of Andrographis paniculata (Burm. ) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery. Molecules, 27(14), 4479. https://doi.org/10.3390/molecules27144479

 

16. Burgos, A., Alarcón, P., Quiroga, J., Manosalva, C., & Hancke, J. (2020). Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular

Metabolism. Molecules, 26(1), 5. https://doi.org/10.3390/molecules26010005

 

17. Chandra, , Kannujia, R., Pandey, R., Shukla, S., Bahadur, L., Pal, M., & Kumar, B. (2016). Rapid quantitative analysis of multi-components in Andrographis paniculata using UPLC- QqQLIT-MS/MS: Application to soil sodicity and organic farming. Industrial Crops and Products, 83, 423–430. https://doi.org/10.1016/j.indcrop.2015.12.091

 

18. Trinh, A., Park, J., Oh, J. H., Park, J. S., Lee, D., Kim, C. E., Choi, H.-S., Kim, S.-B.,

Hwang, G. S., Koo, B. A., & Kang, K. S. (2020). Effect of Herbal Formulation on Immune Response Enhancement in RAW 264.7 Macrophages. Biomolecules, 10(3), 424. https://doi.org/10.3390/biom10030424

19. Extraction techniques of Medicinal plants. (n.d.). https://agritech.tnau.ac.in/horticulture/extraction_techniques%20_medicinal_plants.pdf
20. ANDROGRAPHIS TINCTURE. (n.d.). Zenmen Retrieved December 25, 2023, from https://zenmenhealth.com/products/andrographis-tincture

 

21. com: Zenmen Andrographis Organic Tincture - Tick Energy Aid and Immune Support, Source of Antioxidants, Boost Immune Defense, Support Healthy Joints, Digestive and Respiratory Health - Made in The USA : Health & Household. (n.d.). Www.amazon.com. Retrieved December 25, 2023, from https://www.amazon.com/Zenmen-Andrographis- Organic-Tincture-Antioxidants/dp/B0CJY27R94